Scientists have discovered a pathway that prevents the buildup of Alzheimer’s Protein:
Researchers have found a pathway named as LC3 associated endocytosis or LANDO. This pathway was found in the microglial cells they are the primary immune cells of the central nervous system and brain. LANDO is a fundamental process that works in the cells throughout the body. They tried their experiment on mice and they found this LANDO that protects against the deposits of neurotoxic b-amyloid protein in it.
When this LANDO is activated then it also guards from neurodegeneration and neuroinflammation includes memory problems. ‘’In the neurodegenerative disease of Alzheimer by activating the LANDO in microglial cells prove to be beneficial through increased the clearance of b-amyloid and alleviation of neuroinflammation’’ said by St. Jude Department of Immunology.
In the laboratory other researcher said that ‘’by inhibiting the LANDO it will boost the effectiveness of cancer immunotherapy.’’ ‘’Although in initial data using a primary brain tumor model suggests that inhibition of LANDO might provide a mechanism to activate inflammation within tumor environment to generate an anti-tumor response.’’
The accumulation of b-amyloid protein is a hallmark of Alzheimer’s disease. Scientists know that b-amyloid protein is taken up by microglial cells. The researcher has compared it with car wash. The car is a receptor that binds b-amyloid protein on the microglial cells and brings it into the car wash. After the car wash, the car gets back on the streets all the dirt is gone and just like that the LANDO disposed of the b-amyloid protein then gets on the microglial cell’s surface to get another b-amyloid protein.
The car wash is based on tracks that keep the car moving through the machine. Like this, the LANDO has proteins such as Rubicon, ATG5 and ATG7, Beclin 1 that help in the functioning of it. They also recycle the unwanted and unneeded components of the cell. But there is one problem and that is these proteins decline with age when their expression decreases.
Herbs and Supplements that help in the treatment of Depression:
Depression is a serious disorder that has symptoms of range from mild to incapacitate and conceivably life threatening. The National Institute of Mental Health suggests that about 6.7 percent people experienced depression. Counseling and medications are the best ways to reduce the symptoms of this depression problem but now some supplement and herbs also work for it.You should know that which herbs are therapeutically beneficial for you. That will save your time and money.
Some herbs and supplement for alleviating the depression discussed below:
- Hypericum Perforatum: It is an herbal plant used to treat the mental illness and worked as in antidepressant medications.
- Lavender: This is an oil and used for relaxing from mood disturbances and reduces anxiety. Improves your sleep.
- 5 HTP: It is known as 5-hydroxytryptophan and this is a supplement. This is used in regulating and improving the level of serotonin in the body. Act as antidepressants.
- Ginseng: This is a supplement found from the plant. Improves mental clarity and energy. Lowers down the stress level.